We are entering the third wave of the artificial intelligence (AI) evolution, which is disrupting and revolutionizing many industries. While some worry about the unchecked expansion of AI, others praise its potential to improve life. This panel will present the framework and terminology of AI and delve into some of its applications and impacts on technology transfer. Speakers from both university and industry will explore the challenges and applications in licensing practices, and describe non-traditional university-industry deals, while exploring applications, including healthcare indications and social media. Proposed solutions will be presented and speakers will address the background and current state of AI patent subject eligibility.